Decalcification describes the technique for removing minerals from bone or other calcified tissue so that good-quality paraffin sections can be prepared that will preserve all the essential microscopic elements.

Leica Biosystems offers a decalcifying agent that could fix and decalcify at the same time. A line of decalcifiers that are color coded to show different acid strengths and reduces exchange errors thanks to visual color cues.

Decalcifier I is ideally for small calcified specimens and Decalcifier II for heavily calcified, larger specimens.